DURUSSEL et al TRANSCRIPTIONAL SIGNATURE OF rHuEPO
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1 | Title: The blood transcriptional signature of recombinant human 1 erythropoietin administration and implications for anti-doping strategies 2 3 Authors: Jérôme Durussel, Diresibachew W. Haile, Kerli Mooses, Evangelia Daskalaki, 4 Wendy Beattie, Martin Mooses, Wondyefraw Mekonen, Neford Ongaro, Edwin Anjila, 5 Rajan K. Patel, Neal Padmanabhan, Martin W. McBride, John D. McClure, and Yannis P. 6 Pitsiladis. 7 8 Affiliations: Institute of Cardiovascular and Medical Sciences, College of Medical, 9 Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom; 10 Department of Medical Physiology, Addis Ababa University, Addis Ababa, Ethiopia; 11 Faculty of Sport and Exercise Sciences, University of Tartu, Tartu, Estonia; Strathclyde 12 Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United 13 Kingdom;Department of Medical Physiology, School of Medicine, College of Health 14 Sciences, Moi University, Eldoret, Kenya; and Centre for Sport and Exercise Science and 15 Medicine (SESAME), University of Brighton, Eastbourne, United Kingdom. 16 17 *Corresponding Author: Professor Yannis P. Pitsiladis 18 Professor of Sport and Exercise Science, Director of the Centre 19 Centre for Sport and Exercise Science and Medicine (SESAME) 20 Hillbrow, Denton Road 21 Eastbourne, BN20 7SP, United Kingdom 22 Email [email protected] 23 Telephone +44 (0) 1273 643707 (Reception) 24 Fax +44 (0) 1273 643704 25 Articles in PresS. Physiol Genomics (January 12, 2016). doi:10.1152/physiolgenomics.00108.2015
منابع مشابه
Blood transcriptional signature of recombinant human erythropoietin administration and implications for antidoping strategies.
Recombinant human erythropoietin (rHuEPO) is frequently abused by athletes as a performance-enhancing drug, despite being prohibited by the World Anti-Doping Agency. Although the methods to detect blood doping, including rHuEPO injections, have improved in recent years, they remain imperfect. In a proof-of-principle study, we identified, replicated, and validated the whole blood transcriptional...
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تاریخ انتشار 2015